# Control of collective cell movement by planar cell polarity signaling

> **NIH NIH R01** · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $83,603

## Abstract

Abstract
Collective cell movements termed convergent extension (CE) drive the elongation of tissues and organs in
essentially all animals. In vertebrates, CE is controlled by the planar cell polarity (PCP) signaling system, and
defects in PCP-dependent convergent extension are associated with human neural tube defects and skeletal
dysplasias. We feel that the profound lack of information regarding the basic cell biology of CE as it occurs in
vertebrate animals in vivo represents the key challenge in the field at this time. Building on our recent
successes in advanced imaging and proteomics, this proposal takes a "cell biological" approach, focusing on
fundamental cellular machines of cadherin adhesion, actin assembly, and the septin cytoskeleton and how
they are deployed to drive PCP-mediated CE.

## Key facts

- **NIH application ID:** 11095690
- **Project number:** 3R01HD099191-09S1
- **Recipient organization:** UNIVERSITY OF TEXAS AT AUSTIN
- **Principal Investigator:** John B Wallingford
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $83,603
- **Award type:** 3
- **Project period:** 2020-07-29 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11095690

## Citation

> US National Institutes of Health, RePORTER application 11095690, Control of collective cell movement by planar cell polarity signaling (3R01HD099191-09S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11095690. Licensed CC0.

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