Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

NIH RePORTER · NIH · R01 · $70,648 · view on reporter.nih.gov ↗

Abstract

We are seeking supplemental funding to purchase an advanced electrophysiological recording system for our project. This project studies the effects of general anesthesia on neuronal activity and oxygen levels in the cerebral cortex, requiring continuous recording via chronically implanted electrodes. Our existing system is old and increasingly unreliable, and moreover, it is insufficient for our experiments, especially when multiple kits are born simultaneously. A new system will allow us to monitor more animals simultaneously and offer improved design and signal quality. The updated system will reduce experimental time, ensure cleaner data, and enable better comparisons between oxygen levels and electrophysiological signals. Acquiring the new Neuralynx system will enhance our recording capabilities, benefiting our current and future research. We seek additional funding to procure this system, confident in its substantial contributions to our work.

Key facts

NIH application ID
11096253
Project number
3R01GM112715-09S1
Recipient
ENDEAVOR HEALTH CLINICAL OPERATIONS
Principal Investigator
Daniil Aksenov
Activity code
R01
Funding institute
NIH
Fiscal year
2024
Award amount
$70,648
Award type
3
Project period
2016-08-15 → 2026-08-31