# Development of Sulfur-Based Reactions with Translational  Applications

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $113,257

## Abstract

Abstract
Synthesis and coupling of hindered and strained functional molecules and bioisosteres represent
underdeveloped yet synthetically powerful transformations. This research project is focused on the discovery of
both stoichiometric and catalytic sulfur mediated couplings, which might that potentially overcome several
limitations often encountered in traditional transition-metal couplings. Our research heavily relies on UPLC
analysis and purification because of the reaction development, molecular complexity and unique physical
properties of sulfurane, boronates, bicyclo[1.1.1]pentanes, sp3-rich amines and other polar bioactive molecules.
The goal of this administrative supplement application is to strengthen the analytical capability of this research
program.

## Key facts

- **NIH application ID:** 11098352
- **Project number:** 3R01GM141088-04S1
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Tian Qin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $113,257
- **Award type:** 3
- **Project period:** 2021-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11098352

## Citation

> US National Institutes of Health, RePORTER application 11098352, Development of Sulfur-Based Reactions with Translational  Applications (3R01GM141088-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11098352. Licensed CC0.

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