# Homeostatic Regulation of PIP2-Calcium Signaling

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $28,218

## Abstract

This is an administrative supplement application for purchasing a stage top incubator to replace the
malfunctioning enclosure-style incubator installed on the confocal-TIRF microscope system in the PI’s
lab more than 15 years ago. A functioning incubator that provides optimal temperature, CO2, and
humidity to keep cells healthy during imaging experiments is critical for the success of the parent
project that heavily relies on live-cell imaging assays to define mechanisms regulating PIP2
homeostasis by Nir2 protein at endoplasmic reticulum (ER)-plasma membrane (PM) junctions during
receptor-induced Ca2+ signaling. The purchase of a new stage top incubator system is urgently
needed to reinstate live cell imaging capability of proposed experiments crucial for the success of the
parent project. A new stage top incubator system will provide a consistent environment for cells to stay
healthy for high-quality and quantitative imaging results which is critical for the awarded project.

## Key facts

- **NIH application ID:** 11098386
- **Project number:** 3R01GM144479-03S1
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** JEN LIOU
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $28,218
- **Award type:** 3
- **Project period:** 2022-07-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11098386

## Citation

> US National Institutes of Health, RePORTER application 11098386, Homeostatic Regulation of PIP2-Calcium Signaling (3R01GM144479-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11098386. Licensed CC0.

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