SUMMARY Nitrogen-rich small molecules are critical to human health as they constitute the vast majority of all known pharmaceutical agents. As the requirements for new drugs become stricter, and as the diseases that are targeted become more complex, the chemical structures of those compounds are also becoming more complex. This is driving the need for more efficient means to prepare ever more complex nitrogen-containing small molecules. The parent R01 Research Project (R01GM145617-03) focuses on the development of new synthetic chemistry methods for preparing nitrogen-rich small molecules by developing novel reactions of electrophilic nitrogen centers. This program relies heavily on the use of High Throughput Experimentation (HTE) to accomplish these goals, but we are currently very limited in our ability to accurately and rapidly measure solids into the 96-well plates used in these work flows. The propose instrument will automate these steps, while providing much greater accuracy and speed. In addition, the on-deck balance of the propose instrument will provide us with exact quantities of added reagents in these experiments, which is critical for accuracy and is currently data we are not able to obtain using the manual pipet methods we are currently employing. The proposed instrument will greatly expand our ability to investigate solid reagents in HTE studies, and thus greatly expedite the proposed research from the parent award.