# Horizontal gene transfer as the source of evolutionary innovation in eukaryotes

> **NIH NIH R01** · MARINE BIOLOGICAL LABORATORY · 2024 · $124,973

## Abstract

This is a supplemental equipment request to the project R01GM111917 in response to NOT-GM-24-021
to purchase a Biacore™ X100 system from Cytiva. This unique piece of equipment takes advantage of
the state-of-the-art technology (surface plasmon resonance) to monitor protein-RNA interactions within
a protein complex consisting of eight monomeric subunits, which is capable of non-templated RNA
tailing in vitro. We will be able to perform RNA binding assays and to determine whether the known
inhibitors of reverse transcriptases would also affect non-templated tailing by the studied group of
reverse transcriptase-like enzymes.

## Key facts

- **NIH application ID:** 11099289
- **Project number:** 3R01GM111917-11S1
- **Recipient organization:** MARINE BIOLOGICAL LABORATORY
- **Principal Investigator:** Irina Arkhipova
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $124,973
- **Award type:** 3
- **Project period:** 2014-08-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11099289

## Citation

> US National Institutes of Health, RePORTER application 11099289, Horizontal gene transfer as the source of evolutionary innovation in eukaryotes (3R01GM111917-11S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11099289. Licensed CC0.

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