# Equipment Supplement: Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2024 · $55,777

## Abstract

Summary of the Request.
We are requesting funds for the purchase of an Agilent 1260 Infinity II LC System to support our ongoing
NIH project R01GM144663-03, “New Methods and Strategies for the Concise Synthesis of Complex Indole
Alkaloids.” This advanced HPLC system, capable of solvent flow rates between 1-10 mL/min, is essential
for both our primary analytical needs and semi-preparative applications. A reliable HPLC is critical for
quantifying product ratios from various reactions, including diastereomers and distinct products, as well as
determining enantiomeric ratios using chiral columns. Our current HPLC, an Agilent 1100 system
purchased in 2005, has become increasingly unreliable, experiencing frequent leaks and severe pressure
spikes that disrupt our research. The acquisition of the Agilent 1260 Infinity II LC System will ensure the
accuracy and reliability of our analytical processes, thereby enhancing the quality and efficiency of our
research. We respectfully request this supplement to maintain the high standards of our ongoing work and
achieve the objectives outlined in our funded project.

## Key facts

- **NIH application ID:** 11100962
- **Project number:** 3R01GM144663-04S1
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** VIRESH H. RAWAL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $55,777
- **Award type:** 3
- **Project period:** 2021-09-10 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11100962

## Citation

> US National Institutes of Health, RePORTER application 11100962, Equipment Supplement: Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products (3R01GM144663-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11100962. Licensed CC0.

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