Project Summary. The overarching goals of this supplement are to understand: (a) how to enhance engagement and participation of hard to reach populations in the UAS, and (b) what is currently missing in our understanding of the sources of inequality due to the lack of representation from certain parts of the population. We will conduct focus groups and in-depth interviews to understand barriers to, and facilitators of, participation in the UAS for populations in disadvantaged communities, as well as to understand current knowledge gaps, with the intent to then develop and test (and eventually implement) a strategy for increasing their representation in the UAS. To be sure, there is no assumption that eventually all interviews will be self-administered and web based. Both the interview mode and questionnaire content will be determined by our findings in this project. Our specific aims are as follows: Aim 1: Investigate the challenges with the UAS’ current recruitment process, survey modality, and frequency for marginalized populations. Aim 2: Enhance understanding of how the UAS should investigate how inequality accumulates over the life course among marginalized groups Aim 3: Develop a strategy for increasing representation of individuals from marginalized populations into the UAS