# MITIGATION OF MULTI-ORGAN DELAYED EFFECTS OF ACUTE RADIATION EXPOSURE (DEARE) WITH ACE-INHIBITOR LISINOPRIL

> **NIH NIH N01** · MEDICAL COLLEGE OF WISCONSIN · 2024 · $998,346

## Abstract

Victims of acute radiation exposure are likely to experience a range of late multi-organ toxicities, which are collectively referred to as delayed effects of acute radiation exposure (DEARE). Currently there are no FDA-approved MCMs for DEARE. Lisinopril is a lead candidate MCM for mitigation of DEARE as it meets all the technical requirements for MCM development under this BAA including prior efficacy in animal studies and an established safety profile in humans. Our main objective is to build on our extensive preclinical experience to forward lisinopril through FDA-licensure as a countermeasure for DEARE. To meet this objective, we have developed the following three milestones. Milestone 1: Lisinopril dose optimization for mitigation of radiation pneumonitis. Milestone 2: Lisinopril efficacy in survivors of hematologic acute radiation syndrome (H-ARS). Milestone 3: Regulatory Activities.

## Key facts

- **NIH application ID:** 11101189
- **Project number:** 75N93023C00013-P00005-9999-1
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** JILL LANDRUM
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $998,346
- **Award type:** —
- **Project period:** 2023-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11101189

## Citation

> US National Institutes of Health, RePORTER application 11101189, MITIGATION OF MULTI-ORGAN DELAYED EFFECTS OF ACUTE RADIATION EXPOSURE (DEARE) WITH ACE-INHIBITOR LISINOPRIL (75N93023C00013-P00005-9999-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11101189. Licensed CC0.

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