The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. Building on 20 years of success, this application proposes the renewal of CCDOR as a VA HSR&D Center of Innovation (COIN) at the Minneapolis VA Health Care System (MVAHCS). The name of the Center has been modified to reflect the Center's strategic goals while preserving the CCDOR acronym and identity recognition. Over the next 5 years, CCDOR's strategic plan focuses on 2 high priority areas in which CCDOR's expertise and partnerships are exceptionally strong and where CCDOR is uniquely positioned to make substantial and meaningful contributions to improving Veteran health and health care: (1) Trauma Recovery, and (2) Chronic Pain and Opioid Harms Reduction. These priority areas are of critical importance to Veterans and their families and are aligned with the VA priorities to enhance foundational services, improve timeliness, and suicide prevention, as well as the Federal Pain Research Strategy. CCDOR's strategic goals are: 1. Conduct research to improve health care, health care experience and outcomes among Veterans with posttraumatic stress disorder (PTSD) and other trauma-related disorders. (Priority 1) 2. Conduct research to reduce opioid-related harms and improve health and functional outcomes for Veterans with chronic pain. (Priority 2) 3. Support and conduct impactful and innovative health services research to discover and support delivery of evidence-based practices on cancer prevention and control, healthy aging, and other important topics outside CCDOR's 2 priority areas. (Additional Research) 4. Train health services researchers to conduct high impact, partner-oriented and implementation-focused research and to become leaders in VA and national health care. (Mentoring and Training) CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducing and promoting research in additional areas. CCDOR's research is enabled by a management structure that includes experienced and dedicated leaders and six Cores to facilitate Center functioning, training and research. The CCDOR Evidence Synthesis and Implementation Cores are known nationally for their methodological expertise and contributions to Veteran health care. CCDOR's Statistics and Data Management Core not only enables CCDOR research but develops new methods and serves as a resource for operational partners, informatics groups and researchers across VHA. The Veterans Engagement Core has expertise in communi...