SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in glioma and the ways to interpret magnetic resonance imaging (MRI) relative to those changes for these key cellular phenotypes. Achieving this objective will require a multi- faceted approach reflected by the multiple projects and cores being proposed. The administrative core will be the primary touchpoint for all pieces of the proposal, overseeing that work is done in an efficient way and providing the necessary administrative support to coordinate all efforts. The central work for our CSBC revolves around extensive analysis of image-localized biopsies that are collected, processed, and stored by Biospecimen Core, analyzed by the Data Integration and Computation Core, and shared between Projects 1 and 2. This highly integrated analysis of image-localized biopsies from GBM patients with clinical imaging will be actively managed by the Administrative Core to ensure a smooth experimental flow with an emphasis on quality and reproducibility. We envision that MOSAIC will serve as a nexus for collaborations focused on the topics revolving around tissue state transitions and clinical imaging across the consortium with likely areas of interest in other cancers beyond glioma. A key function of the Administrative Core will be to actively cultivate such collaborations through coordination with our Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse perspectives on this critical topic. These activities will extend both to collaborations between institutions involved in the Mayo/Columbia CSBC and collaborations across the U54 and U01 holders within the CSBC and PSON networks. In the Administrative Core, our aims—to manage center logistics and communication, administer Intra-Center Pilot Projects, and create and support the External Advisory Committee—will support all aspects of our application. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business, administrative and scientific management of Center activities.