ABSTRACT Women living with HIV (WLWH) in Vietnam face multifaceted vulnerabilities where HIV stigma and gender disparities intersect with challenges stemming from a patriarchal, family-oriented culture. Leveraging evidence- based interventions to address these critical gaps in healthcare for WLWH is crucial. This proposed supplement, titled “Enhancing Family-Centered Interventions for Women with HIV/AIDS in Vietnam Through Implementation Science” involves mentored implementation science research aimed at identifying and adapting evidence-based, family-centered interventions tailored to the cultural and societal context, as well as the specific needs of WLWH in Vietnam. This administrative supplement proposal builds upon our current Cutting-edge, Customized, and Comprehensive (CCC) HIV Capacity Building Program for Vietnam and Thailand (D43TW012489; 2024-2028), a collaboration among University of California, Los Angeles (UCLA), Hanoi Medical University (HMU), and Chiang Mai University (CMU). Junior faculties/researchers at HMU who possess enthusiastic research interests in implementation science and women’s health (Dr. Dinh Thanh Thuy and Mr. Giang Trường Nguyễn) will serve as Co-Investigators of this mentored research. The supplement is structured around three components with corresponding aims: 1) identifying existing family-centered interventions for WLWH through a comprehensive scoping review and systematic evaluation by a Community Advisory Board using the Hexagon Tool; 2) investigating the features and attributes of evidence-based interventions that influence their acceptability among WLWH and their partners through conjoint analysis; and 3) adapting the most promising interventions for local health systems using World Café discussions to ensure cultural congruence. This research initiative will yield crucial insights into evidence-based strategies that empower WLWH and their families in Vietnam, enhancing their engagement with healthcare services and improving health outcomes. Additionally, the project will significantly strengthen local research capacity by providing practical, hands-on training in implementation science theoretical frameworks and methodologies to junior researchers and graduate students at HMU. This training will equip them to lead future health interventions and research, thereby enhancing the quality of healthcare provision for WLWH in Vietnam and potentially in other similar contexts globally.