# Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $198,750

## Abstract

Project Summary/Abstract
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-
24-044”.The ultimate goal of this proposal is to address a fundamental gap in knowledge on the role of CCNE1
driving metabolism in uterine serous carcinoma (USC). The results from these studies could have a significant
impact on the mechanistic understanding of the ~20-30% of USC tumors with CCNE1 amplification. This re-
search plan focuses on assessing the homologous recombination (HR) proficiency of CCNE1hi USC and the
contribution of nucleocytoplasmic acetyl-CoA metabolism and its associated histone acetylation to this pheno-
type. Moreover, they will provide a more global understanding of metabolic reprogramming in CCNE1hi USC and
identify novel therapeutic strategies to synergize with standard-of-care DNA damaging chemotherapies. The
completion of the scientific aims of this proposal will not only provide new mechanistic insights into the interplay
between the acetyl-CoA-mediated metabolic-epigenetic axis in USC, but will also establish targeting metabolism
in this highly aggressive disease. The proposed research is of high impact because little is known about molec-
ular mechanisms driving CCNEhi USC. Moreover, these studies have the potential to impact the management of
CCNEhi USC.

## Key facts

- **NIH application ID:** 11123699
- **Project number:** 3R01CA259111-04S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Katherine Marie Aird
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $198,750
- **Award type:** 3
- **Project period:** 2024-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11123699

## Citation

> US National Institutes of Health, RePORTER application 11123699, Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer (3R01CA259111-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11123699. Licensed CC0.

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