# Breakthrough Technology to Expedite the Democratization of High Field MRI

> **NIH NIH R56** · UNIVERSITY OF MINNESOTA · 2024 · $499,291

## Abstract

ABSTRACT
Technology will be developed to enable future compact, mid-field (0.7 Tesla) magnetic resonance imaging (MRI)
systems, for improving human health worldwide. MRI is an indispensable imaging tool that provides 
measurement capabilities unavailable with other modalities. Yet, due to its expense, large size, and demand on 
facility infrastructure, high quality MRI remains inaccessible to a large fraction of the world’s population, 
particularly in remote and resource-limited settings. The existence of portable, affordable, high-performing MRI 
technology will substantially expand its accessibility for both clinical care and neuroimaging research. Although 
low field (<0.1 Tesla) MRI scanners are now commercially available, to date they have not produced images of 
similar quality as those of mid- and high-field MRI scanners unless relying on intensive post-processing based 
on machine-learning and AI, which makes the reliability of these low field images uncertain at this time. As an 
alternative approach for increasing portability, and thus increasing access to mid-field MRI (0.1 - 1 Tesla), in this 
project we will further develop new technology called FREE (Frequency-modulated Rabi-Encoded Echoes) that 
has potential to eliminate one of the most expensive and massive hardware components of an MRI system; 
namely, the pulsed field gradients that are conventionally used to encode spatial information in MRI. Instead, the 
MR signals will be encoded by spatially varying radiofrequency (RF) fields, using specialized multi-channel RF 
coils and a novel frequency-swept pulse technique that performs spatial encoding using RF field gradients, even 
when the magnet produces a highly nonuniform field. Further, this project will build upon the previous innovations 
by this same team in a U01 grant that led to: 1) the capability to perform MRI with extreme magnetic field 
inhomogeneity (~2-3 orders of magnitude greater than what is commonly perceived to be necessary), 2) a unique 
compact high temperature superconducting (HTS) head-only magnet, and 3) a state-of-the-art multi-channel 
digital spectrometer for programming and controlling the MRI scanner. The research in this R56 project will 
involve computer simulations and experimental tests using the HTS head-only MRI scanner operating at 0.7
Tesla. We will develop a multichannel RF coil and multi-echo 2D-FREE imaging with parallel RF transmission 
and reception. Products will include new MRI methods, software, and hardware to achieve highly portable midfield MRI. Future portable mid-field MRI scanners based on this new technology will help people in remote, 
resource-limited settings to address health inequities.

## Key facts

- **NIH application ID:** 11124390
- **Project number:** 1R56EB033347-01A1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** MICHAEL GARWOOD
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $499,291
- **Award type:** 1
- **Project period:** 2024-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11124390

## Citation

> US National Institutes of Health, RePORTER application 11124390, Breakthrough Technology to Expedite the Democratization of High Field MRI (1R56EB033347-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11124390. Licensed CC0.

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