# Tobacco Use and Cessation, HIV, and TB in South Africa: Clinical and Economic Outcomes (Clinical and public health approaches to tobacco cessation in South Africa supplement)

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $166,988

## Abstract

SUPPLEMENT PROJECT SUMMARY
Approximately 80% of people who use tobacco live in low- and middle-income countries. In South Africa, an
upper-middle-income country, tobacco smoking prevalence among adults was 26% in 2021. South Africa is
also home to the world’s largest HIV epidemic. As improved access to antiretroviral therapy has decreased
deaths from advanced HIV disease, tobacco-related diseases account for an increasing proportion of deaths
among people with HIV. Clinical and public health strategies to decrease tobacco use are urgently needed in
South Africa and elsewhere in sub-Saharan Africa, where tobacco use is rising.
We conducted a telephonic survey about tobacco use among a subset of participants in the Vukuzazi program,
a large community-based cohort study in rural KwaZulu-Natal, South Africa, investigating the intersection of
communicable and non-communicable diseases. Recognizing an obligation to address tobacco dependence,
we developed and provided a brief telephonic tobacco cessation counseling intervention for people who
reported actively using tobacco. Additionally, we inquired about participants’ tobacco use before, during, and
after South Africa’s 2020 tobacco sales ban.
In this supplement project, we will analyze these data to evaluate the impact of telephonic tobacco cessation
counseling (clinical intervention) and the tobacco sales ban (public health intervention) on tobacco use among
people with and without HIV in rural South Africa. The results of this project will provide valuable information to
public health officials, clinicians, HIV care programs, and policymakers about targeted approaches to decrease
tobacco use.

## Key facts

- **NIH application ID:** 11126424
- **Project number:** 3R01DA050482-05S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Krishna P Reddy
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $166,988
- **Award type:** 3
- **Project period:** 2020-09-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11126424

## Citation

> US National Institutes of Health, RePORTER application 11126424, Tobacco Use and Cessation, HIV, and TB in South Africa: Clinical and Economic Outcomes (Clinical and public health approaches to tobacco cessation in South Africa supplement) (3R01DA050482-05S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11126424. Licensed CC0.

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