# NIH Aplysia Renewal Year 29 - 33

> **NIH NIH P40** · UNIVERSITY OF MIAMI ROSENTEIL SCHOOL · 2024 · $134,588

## Abstract

The proposed diversity supplement will fund a two-year postdoctoral fellowship for
Dr. Javier Rodriguez Casariego within the National Resource for Aplysia supervised
by co-mentors Drs. Michael Schmale and Danielle McDonald. Appropriate plans are in
place to support educational and career development objectives of the candidate as
well as to provide training in the responsible conduct of research. The proposed
research program will continue experiments that explore how sub-lethal exposure to
hypoxia can modulate future responses to stress and the molecular mechanisms
involved in this type of memory, primarily through epigenetic mechanisms. Aims of the
project include the characterization of DNA methylation and non-coding RNAs in
hypoxia resistant and sensitive phenotypes, identify epigenetic markers supporting the
transgenerational inheritance of resistance, and the role of these mechanisms
regulating gene expression programs in the nervous system of Aplysia. This project is
consistent with the aims of the parent grant by expanding the use of Aplysia as a model
for health-related research in areas like neuroprotection to stroke and other
neurodegenerative diseases, and contributing to the development of an
ischemia/reperfusion injury model in this species.

## Key facts

- **NIH application ID:** 11128058
- **Project number:** 3P40OD010952-29S1
- **Recipient organization:** UNIVERSITY OF MIAMI ROSENTEIL SCHOOL
- **Principal Investigator:** MICHAEL C SCHMALE
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $134,588
- **Award type:** 3
- **Project period:** 2024-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11128058

## Citation

> US National Institutes of Health, RePORTER application 11128058, NIH Aplysia Renewal Year 29 - 33 (3P40OD010952-29S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11128058. Licensed CC0.

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