# Administrative Supplement to U54 DA049115: Exploring Immune Transcriptome Signatures in the Development of Chronic Pain

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $79,877

## Abstract

Summary
This Administrative Supplement request aims to perform single nucleus gene expression studies (snGEX) on
white blood cells from buffy coat samples collected as part of the Acute to Chronic Pain Signatures (A2CPS)
program. snGEX will be assessed at two timepoints per individual: baseline and 3 months post knee
replacement surgery. Gene expression profiles from subjects who develop chronic pain will be compared to
profiles from those who do not.

## Key facts

- **NIH application ID:** 11128257
- **Project number:** 3U54DA049115-06S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Kathleen Marie Fisch
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $79,877
- **Award type:** 3
- **Project period:** 2019-09-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11128257

## Citation

> US National Institutes of Health, RePORTER application 11128257, Administrative Supplement to U54 DA049115: Exploring Immune Transcriptome Signatures in the Development of Chronic Pain (3U54DA049115-06S1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/11128257. Licensed CC0.

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