# UPENN Scientific and Data Research Center for the HOPE Consortium to Reduce Pain and Opioid Use in Hemodialysis

> **NIH NIH U01** · UNIVERSITY OF PENNSYLVANIA · 2024 · $1

## Abstract

Project Summary
This is an application from the Center for Clinical Epidemiology and Biostatistics and the Renal, Electrolyte and
Hypertension Division, the Department of Neurology, and the Department of Psychiatry at the University of
Pennsylvania Perelman School of Medicine to serve as the Scientific and Data Research Center (SDRC) for
the Hemodialysis Opioid Prescription Effort (HOPE) Consortium. Through this HEAL / NIDDK initiative, the
HOPE Consortium will collaboratively design and conduct a multicenter clinical trial evaluating interventions to
address the challenging problems of chronic pain and opioid use in individuals receiving treatment with
maintenance hemodialysis. We anticipate that the HOPE Consortium investigators will consider behavioral,
complementary, and pharmacologic interventions, personalized treatments based on psychosocial profiles,
adaptive designs to maximize efficiency, and approaches to the delivery of the interventions and acquisition of
data that minimize burden for patients by “bringing the trial to the participant”. Specifically, the SDRC will:
1) provide scientific leadership for the design, implementation, and analysis of the HOPE Consortium clinical
trial; 2) provide comprehensive operational support to the Clinical Centers for implementing the collaboratively
designed trial protocol using standardized processes and tools for training, recruitment, and data management;
3) develop and lead a Stakeholder Engagement Working Group that includes a Patient Advisory Panel and a
Dialysis Provider Advisory Panel to ensure that perspectives across multiple stakeholders are incorporated into
the trial design and implementation approach; 4) integrate and analyze data from the electronic health records
of the participating Clinical Centers to supplement trial-acquired data and enable identification of predictors of
response to the trial interventions; 5) establish, promote, and maintain consortium-wide high standards for
quality assurance and practices; 6) initiate and oversee contracts with industry partners including dialysis
provider organizations, pharmaceutical companies, and device manufacturers; 7) prepare reports for the Data
and Safety Monitoring Board, and support the preparation of Consortium reports of scientific findings;
8) prepare, document, and transfer Consortium data and biosamples to the NIDDK Central Repository for use
by the broader community; and 9) develop approaches for disseminating the trial findings to diverse
stakeholders to facilitate post-trial uptake of interventions found to be beneficial. The University of
Pennsylvania SDRC team has the expertise, experience, established working relationships, resources, and
infrastructure to accomplish each of these aims and fulfill all of the requirements specified in the RFA.

## Key facts

- **NIH application ID:** 11130438
- **Project number:** 4U01DK123813-02
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Laura M Dember
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1
- **Award type:** 4N
- **Project period:** 2019-09-24 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11130438

## Citation

> US National Institutes of Health, RePORTER application 11130438, UPENN Scientific and Data Research Center for the HOPE Consortium to Reduce Pain and Opioid Use in Hemodialysis (4U01DK123813-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11130438. Licensed CC0.

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