# Novel roles of hepatic fatty acid oxidation

> **NIH NIH R56** · JOHNS HOPKINS UNIVERSITY · 2024 · $409,375

## Abstract

Modified Project Summary/Abstract Section
The liver is central to mammalian metabolism and plays a critical role in providing fuel to other tissues
particularly when food is limiting. People with disparate inborn errors in mitochondrial fatty acid β-oxidation 
exhibit life-threatening hypoketotic-hypoglycemia following a fast due to the critical role of fatty acid oxidation to
gluconeogenesis and ketogenesis. To understand the contribution of hepatic fatty acid oxidation to systemic
metabolic dysfunction, we have generated multiple transgenic mice with an altered ability to oxidize long chain 
fatty acids via mitochondrial β-oxidation specifically in hepatocytes. Here we will leverage extensive genetic
models to understand the contribution of fatty acid oxidation to hepatic and extrahepatic regulation of hepatic
and systemic metabolic homeostasis. The expectation is that our proposed studies will describe novel
requirements and signaling roles of hepatic fatty acid oxidation that impact the development of obesity and
glucose intolerance.

## Key facts

- **NIH application ID:** 11134914
- **Project number:** 1R56DK138507-01A1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Michael J. Wolfgang
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $409,375
- **Award type:** 1
- **Project period:** 2024-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11134914

## Citation

> US National Institutes of Health, RePORTER application 11134914, Novel roles of hepatic fatty acid oxidation (1R56DK138507-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11134914. Licensed CC0.

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