# The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth

> **NIH NIH F30** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $53,974

## Abstract

Project Summary
This application describes the research plan and program of study leading to a PhD as part of a combined MD-
PhD Program at the University of Nebraska Medical Center and the Boys Town National Research Hospital. The
central goal of this research plan is to identify how dehydroepiandrosterone (DHEA), testosterone, and estradiol
modulate the development of cognitive systems serving selective attention and working memory processing.
Briefly, the pubertal transition period is marked by significant increases in these hormones and substantial
developmental advancements in higher-order cognitive functions, including working memory, selective attention,
and others. However, on the other hand, the incidence of psychiatric disease also increases during puberty, and
is accompanied by greater sex differences in disease prevalence. It has been suggested that this emergence of
psychiatric illness during puberty might be associated with the drastic hormonal changes that mark this
developmental stage, but the net impact of these hormonal changes on brain function and cognition is poorly
understood.
This F30 fellowship proposal will examine the sex and region-specific effects of DHEA, testosterone, and
estradiol on working memory and selective attention processing using an advanced dynamic functional mapping
approach based on magnetoencephalography (MEG), and includes a rigorous training and career development
plan for a future physician-scientist in the areas of pediatric psychiatry and developmental cognitive neuro-
science. The specific aims are (1) to examine the unique effects of pubertal hormones in predicting performance
on selective attention and working memory tasks and (2) to identify the relationship between sex steroid hormone
levels, neural oscillatory dynamics, and behavior during attention and working memory tasks. The trainee is a
minority MD/PhD student in his 2nd year of PhD study who has already distinguished himself through two first-
authored manuscripts in top journals, participation and presentation in scientific conferences, and a strong history
of academic achievement. In sum, this application for an F30 fellowship will use MEG, advanced source
reconstruction methods, neural oscillatory analyses, and hair-sampled hormone analysis to delineate the
relationship between pubertal hormone levels, brain dynamics, and cognitive development. The program of study
is designed to support this research plan through rigorous training by an internationally known expert in MEG
and dynamic brain mapping who has a strong record of mentoring trainees, as well as an expert collaborator in
pubertal hormone analysis and interpretation, with the primary goals of developing and expanding the research
and clinical skills of the applicant to produce a physician-scientist who is well equipped and prepared for the next
stage of his career.

## Key facts

- **NIH application ID:** 11138379
- **Project number:** 7F30MH130150-03
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** Abraham Killanin
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $53,974
- **Award type:** 7
- **Project period:** 2024-09-13 → 2026-09-12

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11138379

## Citation

> US National Institutes of Health, RePORTER application 11138379, The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth (7F30MH130150-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11138379. Licensed CC0.

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