PROJECT SUMMARY Administrative Core The Administrative Core is responsible for the overall leadership, management, and execution of the ROBIN center, and it will provide overall organizational, administrative, scientific and clinical management. The Administrative Core will oversee and coordinate all ROBIN program components and centrally monitor and evaluate their performance. In addition, the Administrative Core will facilitate all interactions with the External Advisory Board (EAB), the Steering Committee, and the other sites of the national ROBIN program. This ROBIN center involves 3 institutions (Cleveland Clinic, Emory University, and Case Western Reserve University), with multiple enrollment sites (Cleveland Clinic system, Cleveland Clinic Florida system, Emory University system) across 2 NCI-designated Comprehensive Cancer Centers (Case Comprehensive Cancer Center, Emory Cancer Center), with representation across these institutions as project and core leaders. The Administrative Core personnel will be led by Drs. Chan, Yu, and Scott, with collaboration from the trial and project leads. Both Drs. Chan and Yu (ROBIN PIs) have extensive experience in managing multi-institution clinical trial and laboratory-based research programs. The specific aims for the Administrative Core are as follows. In Aim 1, the Core will provide all organizational, administrative, educational, and scientific coordination for the ROBIN center projects and cores by cultivating and promoting the ROBIN team through innovation and excellence, collaboration, leveraging resources, and providing constructive feedback. In Aim 2, the Core will provide centralized administrative management for all fiscal aspects of the ROBIN center, including but not limited to clinical trial execution, accounting of grant funds, progress reports, communication, meeting scheduling and minutes, and manuscript and grant preparation. In Aim 3, the Core will evaluate research progress through oral and written documentation, with regular input from the EAB, Steering Committee, and National Cancer Institute (NCI) leadership to ensure that each project meets its objectives within the proposed time frame and to facilitate interactions with other ROBIN sites for trans-ROBIN center projects. In Aim 4, the Core will ensure integration across ROBIN components, including projects and cores, across all sites, and provide interaction through scientific exchanges, coordination of an annual scientific retreat, and through training and development plans that will ensure state-of-the-art practices. In Aim 5, the Core will ensure and monitor best practices for human subjects and animal research for all ROBIN center projects and cores as well as clinical and data operations, and to ensure adequate human and animal biospecimens for all projects (with the Translational and Clinical Correlates Core).