Project Summary Institutional efforts are required to achieve the level of diversity, equity, and inclusion that will ensure recruitment and advancement of individuals now underrepresented in academic medicine (URiM). Siteman Cancer Center (SCC) is committed to overcoming structural barriers that have limited diversity in the cancer research workforce and to supporting the success of early career cancer researchers. Aligned with the NCI National Cancer Plan Goals to eliminate inequities and to optimize the workforce, and with the support of a CCSG Supplement, SCC has implemented a Training Navigation program. The overarching goal of this program is to provide personalized navigation to resources and services that enhance the career development and trajectory of early career scholars (particularly postdoctoral fellows and early-stage investigator faculty), including women and those from backgrounds that are URiM. This SCC effort is a collaboration between Cancer Research Training and Education Coordination (CRTEC) and Plan to Enhance Diversity (PED). Importantly, CRTEC and PED staff collaborate to ensure that early career scholars benefit from navigation support and programming, and that all SCC scholars receive exceptional support during graduate school, postdoctoral work, and as ESI faculty. We previously trained a PED staff member as a training resource navigator to provide hands-on support and link scholars to career development resources and programs. To support scholars, particularly URiM and women, we will continue to evaluate, improve, and sustain our training navigation infrastructure and programs in order to promote resource access and build a climate conducive to persistence and success in cancer research careers. Our aims are to: (1) Identity competitive and promising underrepresented cancer-focused trainees and ESI faculty within SCC and the region; (2) Provide personalized navigation to resources, professional preparation, and networking opportunities; and (3) Evaluate program outcomes and evolve the program as needed to meet changing needs and opportunities, while implementing plans for sustainability of our high-impact activities. Our objective is to conduct activities that improve the training climate and increase participation of URiM and women scholars in training and career development programming. Navigation is a key strategy for linking scholars to the supports they need and want, and we have planned a sustainable approach. Specific initiatives include proactive and personalized navigation, grant writing and biosketch training, access to scientific editing and grant reviews, support for travel to cancer conferences, and other professional development opportunities. Short-term outcomes include equity and inclusion in scholars reached and supported, scholars linked with NCI program officials, participation in training activities, and grant submissions including career development awards and diversity supplements. Longer-term ou...