Abstract Through this proposed new supplemental award, the UCLA Jonsson Comprehensive Cancer Center Community Outreach and Engagement (JCCC COE) team will collaborate with community partners, the Mixteco Indigena Community Organizing Project (MICOP) and Antelope Valley Partners for Health (AVPH) to develop and disseminate tailored multi-channel communication campaigns to promote cancer screening and tobacco control in predominately low-income Latinx communities in two high need regions served by the JCCC. In keeping with Track 2 of this funding opportunity, campaigns will focus on the general population, ages 30 and over, promoting breast, cervical and colorectal cancer screening, and raising awareness about lung cancer screening. MICOP works to aid and empower the Indigenous immigrant agricultural community in Ventura County, California. This community faces many obstacles to accessing health care, including linguistic barriers as many community members speak only their native non-written languages. MICOP's radio station broadcasts in Indigenous languages, providing an important means of imparting information to the community. The Antelope Valley (AV) is one of the least densely populated and most economically challenged areas of Los Angeles County, with relatively few health and social service resources. AVPH is a non-profit community collaborative dedicated to improving the lives of underserved residents in the AV. Building on the successes and lessons learned through our collaborative efforts in the ongoing UCLA MICEO supplement, and with continued guidance from our Project Advisory Committee, we will craft, disseminate and evaluate messages tailored to meet the specific needs and preferences of the communities served by our partner organizations. We expect to reach a total of 78,500 community members, including 70,000 residents via MICOP's radio station and via social media campaigns incorporating audio overlay in Indigenous languages and 8,500 residents through AVPH, via social media and community health worker outreach. We will track campaign reach and numbers of residents who seek screening because of our campaigns. Brief surveys with community members will assess cancer screening knowledge and awareness and interviews with clinic staff and community health workers will examine which aspects of campaigns were most impactful. The JCCC COE team has decades of experience collaborating with community organizations, including MICOP and AVPH. We are eager to build on lessons learned in the first project year and will utilize the extended project period to craft toolkits for each campaign, to support sustained implementation by our partners and widespread dissemination to other local partners as well as via state and national networks. The proposed work is closely aligned with the mission of the JCCC and COE to reduce cancer disparities through outreach and engagement activities in the most affected communities.