PROJECT ABSTRACT Childhood cancer survivors are a high-priority, underserved population for HPV vaccination. They are less likely to be vaccinated when compared to the general population and are more likely to develop second cancers caused by HPV as adults. St. Jude Comprehensive Cancer Center (SJCCC) is uniquely positioned to address observed disparities in HPV vaccination coverage among childhood cancer survivors by leveraging our unique reach across our catchment area and building on award-winning, state-of-the-art communication systems with those treated at SJCCC and their families. The purpose of this proposal is, therefore, to further develop, optimize, and evaluate the Survivor Proud campaign to promote HPV vaccination to childhood cancer survivors (Track 1: 9-30 years). We will focus specifically on continuous quality improvement of the campaign through ongoing evaluation activities and successfully sustaining elements of the campaign that are most effective. We also will focus on important wrap-around activities in support of the communication campaign, including peer-to-peer efforts for patient families and clinician education and training. We will leverage established infrastructure and collaborations to achieve the following specific aims: 1) Optimize and expand the innovative, culturally targeted, multi-channel Survivor Proud communication campaign to enhance health literacy related to HPV vaccination and to improve HPV vaccination coverage among CCS; and 2) Evaluate the impact of the campaign to understand its impact on awareness, knowledge, intentions to get HPV vaccination, and actual HPV vaccination, when data are available. Our approach will be highly iterative and include engagement of key offices within St. Jude and most importantly, through our continued regular interaction with patient families and adult childhood cancer survivors. The Survivor Proud campaign focuses on web-based resources and communities, social media platforms, mobile application (app), traditional print formats, electronic medical record (EMR) prompted patient education prescriptions, direct e-communication, peer-to- peer, patient family experiences, and clinician training and education. The Survivor Proud HPV vaccination campaign has first been developed in English (and will be developed in Spanish) will be evaluated across these communication channels. A focus of the campaign is to build confidence in HPV vaccination leveraging the trusted relationship patient families have with St. Jude. Project activities are documented and monitored through a comprehensive process evaluation. Preliminary impact of our efforts will also be measured using qualitative, quantitative, and analytical data, including assessment of aggregated HPV vaccination rates before and after campaign implementation. Our efforts will be aligned with existing St. Jude resources from the beginning to optimize sustainability. We will openly share our findings with other cancer centers and ...