# Center for Biomedical OCT Research and Translation

> **NIH NIH P41** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $199,999

## Abstract

Project Summary
Polarization-sensitive optical coherence tomography (PS-OCT) was introduced more than 20
years ago but has only recently reached the level of technological maturity needed to support
biomedical translation. Today, PS-OCT is one of the most exciting methods in OCT and
promises to open a new set of doors in applications from intravascular cardiology to nerve-
sparing in surgery. However, specialized phantoms are needed to support the development of
PS-OCT but are not broadly available. Our P41 Center has developed PS-OCT phantoms that
we have used to support our internal PS-OCT development, but which require careful and
unpredictable fabrication methods. Here, we propose modifications and optimizations to the
phantom design to allow these PS-OCT phantoms to be easily made by any group using
broadly available materials. By developing and sharing these phantoms through the NIST/NIBIB
Imaging Phantom Library, this work can act to accelerate PS-OCT development and translation
and to enhance the robustness and interpretability of PS-OCT imaging study results.

## Key facts

- **NIH application ID:** 11159067
- **Project number:** 3P41EB015903-13S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Brett E Bouma
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $199,999
- **Award type:** 3
- **Project period:** 2024-09-05 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11159067

## Citation

> US National Institutes of Health, RePORTER application 11159067, Center for Biomedical OCT Research and Translation (3P41EB015903-13S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11159067. Licensed CC0.

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