# Rational Systemic Characterization and Selection of Adjuvants for HIV Vaccine Candidates (R-CASA)

> **NIH NIH N01** · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $1,990,835

## Abstract

The successful development of an HIV vaccine with novel adjuvants depends on the selection of the most appropriate immunogen-adjuvant formulations. The R-CASA contract, which is focused on HIV vaccine development, will provide an opportunity to develop new approaches to assess optimal HIV immunogens-adjuvants formulations prior to transitioning into clinical trials. R-CASA will 1) generate and propose standardized protocols and endpoint assays for rational and systematic down-screening of HIV immunogen-adjuvant formulations, 2) apply those protocols and assays to screen HIV immunogen-adjuvant formulations, and 3) screen additional immunogens and adjuvants at the direction of NIAID. These efforts will delineate a standardized set of assays for biochemical and immunological characterization of HIV immunogen-adjuvant formulations, down-selection workflow, and go-no-go criteria to maximize the successful transition of immunogen-adjuvant formulations from the pre-clinical testing to First in-Humans (FIH) trials.

## Key facts

- **NIH application ID:** 11161215
- **Project number:** 75N93024C00053-0-9999-1
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** Arnab Kumar Chatterjee
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,990,835
- **Award type:** —
- **Project period:** 2024-08-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11161215

## Citation

> US National Institutes of Health, RePORTER application 11161215, Rational Systemic Characterization and Selection of Adjuvants for HIV Vaccine Candidates (R-CASA) (75N93024C00053-0-9999-1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11161215. Licensed CC0.

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