# ECHO Coordinating Center (CC) -  Administrative Supplement

> **NIH NIH U2C** · DUKE UNIVERSITY · 2024 · $4,100,000

## Abstract

Project Summary:
To address knowledge gaps involving the impact of environmental exposures on health outcomes in children,
the Environmental influences on Child Health Outcomes (ECHO) program leverages extant and new pediatric
cohorts to test new hypotheses of how environmental exposures impact pediatric health. The Duke Clinical
Research Institute (DCRI) serves as the ECHO Coordinating Center (ECHO CC) to provide the organizational
framework for the management, direction, and overall coordination of all common ECHO activities.
To facilitate innovative, rigorous study protocols tailored to the scientific hypotheses; implement protocols
across a network of pediatric cohorts; and provide study support to ensure high quality study operations and
timely completion, the DCRI will use the proposed Administrative Supplement to conduct expanded scope of its
Oversight and Project Management Component.
The specific aims of the Administrative Supplement, led by Dr. Brian Smith, are to:
1) Support implementation of a standardized ECHO Cohort Protocol and monitor progress of individual Cohort
Study Sites.
2) Maintain central IRB functions, translate study- and site-level ECHO Cohort branded communications for
recruitment, enrollment, retention, and dissemination into Spanish, and maintain the ECHO Cycle 1
biorepository at Fisher Bioservices until transfer to the ECHO Laboratory Core at Vanderbilt University.
3) Support efforts to conduct an evaluation of intervention research conducted through the ECHO IDeA States
Pediatric Clinical Trials Network (ISPCTN).

## Key facts

- **NIH application ID:** 11161752
- **Project number:** 3U2COD023375-08S2
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Linda S Adair
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $4,100,000
- **Award type:** 3
- **Project period:** 2024-09-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11161752

## Citation

> US National Institutes of Health, RePORTER application 11161752, ECHO Coordinating Center (CC) -  Administrative Supplement (3U2COD023375-08S2). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11161752. Licensed CC0.

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