# PK/PD and Effect of T-5224 on HIV-1 Transcriptional Activity in an HIV-1-Mouse Model

> **NIH NIH N01** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $849,004

## Abstract

Preclinical Services for HIV Therapeutics: The purpose of these Indefinite Delivery/Indefinite Quantity contracts is to provide the extramural scientific community with research materials and preclinical product development support for candidate products that emerge from investigator-initiated research studies or from collaborations with private sector or academic partners. The scope of work encompasses activities that range from basic research and initial product discovery to activities required for clinical trials and/or product licensure. These services may also be used to support product discovery and development leading to Investigational New Drug Application (IND), Investigational Device Exemption (IDE), and/or New Drug Application (NDA) filings with the Food and Drug Administration (FDA). NIAID Division of AIDS will primarily use these contracts to fill critical development and resource gaps more rapidly and efficiently and advance promising products into clinical testing. The purpose of this task order is to assess the tolerability, pharmacokinetics, and latency-blocking activity of the AP-1/c-Fos
inhibitor, T-5224, in humanized mice.

## Key facts

- **NIH application ID:** 11164957
- **Project number:** 75N93021D00006-0-759302400001-1
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** Santhi Gorantla
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $849,004
- **Award type:** —
- **Project period:** 2024-08-01 → 2025-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11164957

## Citation

> US National Institutes of Health, RePORTER application 11164957, PK/PD and Effect of T-5224 on HIV-1 Transcriptional Activity in an HIV-1-Mouse Model (75N93021D00006-0-759302400001-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11164957. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*