DEVELOPMENT OF A NOVEL PLASMA PROTEIN BIOMARKER PANEL FOR A RADIATION/NUCLEAR TRIAGE BIODOSIMETRY DEVICE (RAPID RAD DX)

NIH RePORTER · NIH · N01 · $1,999,782 · view on reporter.nih.gov ↗

Abstract

Develop a protein-based biomarker multiplexed lateral flow assay (LFA) as a rapid qualitative radiation/nuclear biodosimetry triage device (RapidRadDx) that can distinguish between exposed and unexposed individuals in a mass-casualty ionizing radiation (IR) incident as early as 24 hours post-exposure and continuing out to 72 hours. The protein biomarker assay is intended for field use, detecting a novel plasma-soluble biomarker panel in small volumes of capillary blood samples obtained using minimally invasive finger pricks.

Key facts

NIH application ID
11165566
Project number
75N93024C00006-0-9999-1
Recipient
SRI INTERNATIONAL
Principal Investigator
HUA LIN
Activity code
N01
Funding institute
NIH
Fiscal year
2024
Award amount
$1,999,782
Award type
Project period
2024-03-01 → 2025-02-28