# Control of Drosophila intestinal homeostasis by RhoGap15b

> **NIH NIH R56** · EMORY UNIVERSITY · 2024 · $381,022

## Abstract

Project Summary/Abstract
The overall goal of this proposal is to understand how organisms as diverse as humans and the fruit flies use
the same molecules to decide when and where cells will divide, especially when they are needed to repair
damaged tissues. The specific focus of this application is a protein that is highly conserved from insects to
humans, and appears to act specifically in the adult gut to support stem cell renewal of this tissue over the
organism's lifespan. Despite its apparent importance to gut homeostasis, the protein has not been the subject
of sustained study. Our preliminary data indicate that acts as a signaling hub that receives inputs from
phospholipids and in turn delivers regulatory outputs onto two highly conserved pathways broadly involved in
human health and disease. We are very excited to leverage the strength of our data to understand how
this protein coordinates these various roles within intestinal stems cells in Drosophila. Our own cells have
a version of this protein, so we believe that our work will shed light on mechanisms that support our stem cells
too.

## Key facts

- **NIH application ID:** 11170830
- **Project number:** 1R56AG085250-01A1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Kenneth H Moberg
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $381,022
- **Award type:** 1
- **Project period:** 2024-09-15 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11170830

## Citation

> US National Institutes of Health, RePORTER application 11170830, Control of Drosophila intestinal homeostasis by RhoGap15b (1R56AG085250-01A1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/11170830. Licensed CC0.

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