# JH-EPICS Administrative Core

> **NIH NIH U54** · JOHNS HOPKINS UNIVERSITY · 2024 · $126,659

## Abstract

JH-EPICS ADMINISTRATIVE CORE SUMMARY
The primary goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH-
EPICS) is to systematically evaluate innate, T cell, and antibody responses to SARS-CoV-2 in peripheral blood
mononuclear cells and serological samples from COVID-19 patients. Through in depth analyses, the JH-
EPICS will identify the modifiers of the immune response and severe COVID-19 and isolate the cellular and
molecular targets for COVID-19 treatments as well as the correlates of protection necessary for SARS-CoV-2
vaccine-induced immunity. The primary objective of the JH-EPICS Administrative Core (AC) is to provide
centralized management, leadership, mentoring, sharing, and dissemination of the data from the proposed
Research Projects and Cores in JH-EPICS to ensure that the overarching research goals can be met. The first
Aim, under the Multiple PI leadership of Drs. Sabra Klein and Andrea Cox, will be to provide administrative and
budgetary management as well as scientific leadership and communication for JH-EPICS. The JH-EPICS AC
will distribute funds, organize monthly research meetings, and ensure integration of the JH-EPICS into the
COVID-19 research and educational networks at Johns Hopkins University. The AC will also develop standard
operating procedures for reviewing requests for specimens from the biorepository and their distribution as well
as the collection, processing, and sharing of data generated by the JH-EPICS and approved by the SeroNet
Steering Committee. The second Aim of the JH-EPICS AC will be to foster engagement with SeroNet and
other network activities. The JH-EPICS AC will participate in all trans-SeroNet initiatives, including
establishment of trans-SeroNet collaborative research projects. Finally, the third Aim of the JH-EPICS AC will
be to enhance dissemination of research findings from the JH-EPICS and establish an evaluation plan.
Dissemination of research findings from the JH-EPICS will involve publications and dissemination of results at
the annual SeroNet meeting, national and international meetings of professional societies, and the monthly
Center-wise research meetings. Development of a JH-EPICS website and social media presence will further
assist with dissemination of research findings to a broader audience. Finally, the JH-EPICS AC will establish a
rigorous evaluation plan, including annual progress reports, site visits, and requested documents (e.g., SOPs)
from NIH. The goal will be to ensure appropriate management and productive dissemination of research and
data from JH-EPICS to the broader community, including through public outreach.

## Key facts

- **NIH application ID:** 11170999
- **Project number:** 3U54CA260492-02S3
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** SABRA L. KLEIN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $126,659
- **Award type:** 3
- **Project period:** 2020-09-30 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11170999

## Citation

> US National Institutes of Health, RePORTER application 11170999, JH-EPICS Administrative Core (3U54CA260492-02S3). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11170999. Licensed CC0.

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