This Administrative Supplement to the ABCD-USA Consortium: Data Analysis, Informatics and Resource Center (DAIRC) supports the ongoing efforts of the DAIRC to develop and maintain the new data release infrastructure and associated workflows for data releases. The infrastructure which will be launched this grant year, along with the release of the 6.0 ABCD Data, is planned to be used for all future data releases. These supplemental activities will allow for broader use of ABCD data, including to better ascertain the use of opioids and fentanyl and their impact on adolescent development and the developing brain. By following more than 10,000 children as they go through adolescence, the ABCD Study is well-positioned to explore how their many experiences including substance initiation and use shape their social, emotional, intellectual, and physical growth. These additional activities are important because the data sharing system/solution needs to be optimized for large datasets (including neuroimaging, genomics) and provide scalable data ingestion, integrated data analytics, and a customized user experience. A central component of the new data release infrastructure is the reimplementation and extension of the Data Exploration and Analysis Portal (DEAP version 2.0), which will feature extended functionality for data download, exploration, statistical analysis, and advanced visualization. The DAIRC is leading the development of DEAP 2.0 and supporting efforts, including the development of backend components, databases, storage infrastructure, and computing infrastructure. This support further funds the DAIRC’s development of more streamlined and standardized internal data management processes which are essential to prepare the tabulated data, file-based data, and metadata for releases on an ongoing basis. As part of this, the DAIRC are migrating to a new database system, and working with contractors to set up and maintain security measures to uphold NIH security requirements. In order to maximize the utility of this improved infrastructure the ABCD data is being re-curated and user-resources are being expanded to better support data users.