# Drug Mechanism of Action-based targeting of tumor subpopulations

> **NIH NIH U54** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $164,500

## Abstract

The primary site of prostate cancer metastasis is bone, which is associated with significant morbidity and mortality; yet there are few curative treatment options, in part due to the characteristic heterogeneity of prostate cancer. Our studies employ novel in vivo models and advanced technological approaches to elucidate tumor cell intrinsic and tumor cell extrinsic mechanisms underlying bone metastasis and response to drug treatment. Our studies may provide new insights that will fine-tune treatment with metastatic prostate cancer.

## Key facts

- **NIH application ID:** 11179583
- **Project number:** 3U54CA274506-02S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** ANDREA CALIFANO
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $164,500
- **Award type:** 3
- **Project period:** 2023-09-19 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11179583

## Citation

> US National Institutes of Health, RePORTER application 11179583, Drug Mechanism of Action-based targeting of tumor subpopulations (3U54CA274506-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11179583. Licensed CC0.

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