# Data Management and Statistical Core

> **NIH NIH U54** · FRED HUTCHINSON CANCER CENTER · 2024 · $242,880

## Abstract

PROJECT SUMMARY - DATA MANAGEMENT AND STATISTICAL CORE (DMSC) 
The Data Management and Statistical Core (DMSC) will provide effective statistical planning and data 
management support to optimize the successful accomplishment of the scientific aims of the Cervical Cancer 
Prevention Partnership (C2P2) Center in Peru and the Dominican Republic. The DMSC will support the 
proposed Clinical Trials Program that will span the continuum of cervical cancer prevention from vaccination 
through treatment. The clinical trials will use a new combination of prevention and treatment methods aimed at 
point-of-care and low-infrastructure support to address the burden of HPV-related cancers in HIV-infected 
persons in low-resource settings. The ultimate intent of these trials is to advance the field toward the 
elimination of cervical cancer among vulnerable populations with HIV. Trial 1 will identify new dosing schedules 
to improve the immunogenicity of HPV vaccination among children living with HIV (CLWH). Trial 2 will 
ascertain the contribution of new technologies to refine algorithms for screening and triage of women living with 
HIV (WLWH). Trial 3 will assess non-surgical immune-based treatments of precancerous lesions to interrupt 
progression to cervical cancer in WLWH. In Aim 1, the DMSC will provide design and analysis support for the 
three clinical trials; in Aim 2 the DMSC will provide secure data management and safety monitoring services; 
and in Aim 3 the DMSC will advance the mission of the science through the application of innovative statistical 
analysis and methods. The DMSC leader Dr. Chen will collaborate closely with the Partnership Center’s 
scientific leadership in the Administrative and Coordinating Core and Clinical Trial Co-Chairs to develop 
efficient and high-quality trials that will impact the prevention of cervical cancer in the Latin America/Caribbean 
region.

## Key facts

- **NIH application ID:** 11183113
- **Project number:** 5U54CA242977-07
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** SAYAN DASGUPTA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $242,880
- **Award type:** 5
- **Project period:** 2019-09-18 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11183113

## Citation

> US National Institutes of Health, RePORTER application 11183113, Data Management and Statistical Core (5U54CA242977-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11183113. Licensed CC0.

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