# MOSAIC: Administrative Core

> **NIH NIH U54** · MAYO CLINIC ARIZONA · 2024 · $12,496

## Abstract

SUMMARY: ADMINISTRATIVE CORE
The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to 
understand tissue state transitions that happen in glioma and the ways to interpret magnetic resonance imaging 
(MRI) relative to those changes for these key cellular phenotypes. Achieving this objective will require a multi-faceted approach reflected by the multiple projects and cores being proposed. The administrative core will be 
the primary touchpoint for all pieces of the proposal, overseeing that work is done in an efficient way and 
providing the necessary administrative support to coordinate all efforts. The central work for our CSBC revolves 
around extensive analysis of image-localized biopsies that are collected, processed, and stored by Biospecimen
Core, analyzed by the Data Integration and Computation Core, and shared between Projects 1 and 2. This 
highly integrated analysis of image-localized biopsies from GBM patients with clinical imaging will be actively 
managed by the Administrative Core to ensure a smooth experimental flow with an emphasis on quality and 
reproducibility. 
We envision that MOSAIC will serve as a nexus for collaborations focused on the topics revolving around tissue 
state transitions and clinical imaging across the consortium with likely areas of interest in other cancers beyond 
glioma. A key function of the Administrative Core will be to actively cultivate such collaborations through 
coordination with our Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot 
Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse 
perspectives on this critical topic. These activities will extend both to collaborations between institutions involved 
in the Mayo/Columbia CSBC and collaborations across the U54 and U01 holders within the CSBC and PSON 
networks.
In the Administrative Core, our aims—to manage center logistics and communication, administer Intra-Center 
Pilot Projects, and create and support the External Advisory Committee—will support all aspects of our 
application. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while 
the Center Program Administrator will provide day-to-day business, administrative and scientific management of 
Center activities.

## Key facts

- **NIH application ID:** 11186081
- **Project number:** 3U54CA274504-02S1
- **Recipient organization:** MAYO CLINIC ARIZONA
- **Principal Investigator:** Kristin R Swanson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $12,496
- **Award type:** 3
- **Project period:** 2023-09-18 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11186081

## Citation

> US National Institutes of Health, RePORTER application 11186081, MOSAIC: Administrative Core (3U54CA274504-02S1). Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/grant/nih/11186081. Licensed CC0.

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