# The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression

> **NIH NIH U54** · FRED HUTCHINSON CANCER CENTER · 2024 · $100,184

## Abstract

Emerging data have linked the gut microbiome to colorectal adenomas, the established early lesions in colorectal cancer (CRC) and de facto targets during screening colonoscopy. However, deficit in our knowledge of the basic science of the gut microbiome and the specific driver mechanisms for inducing adenoma formation and progression has impeded translation. We hypothesize that the microbiome is an adenoma nonautonomous inducer of colorectal “priming,” the term we use in this application to refer to molecular/cellular alterations critical for adenoma formation and progression. The near-term objective of this proposal is to define whether and how the microbiome and the primed colon act in concert to drive adenoma formation. The long-term objective of this proposal is to develop microbiome-based strategies for precision prevention of adenomas and ultimately CRC.

## Key facts

- **NIH application ID:** 11187468
- **Project number:** 3U54CA274374-03S1
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** Neelendu Dey
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $100,184
- **Award type:** 3
- **Project period:** 2022-09-20 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11187468

## Citation

> US National Institutes of Health, RePORTER application 11187468, The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression (3U54CA274374-03S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11187468. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*