# Imperial County Clinical Research Network for Health Equity (Administrative Supplement)

> **NIH NIH UH3** · SAN DIEGO STATE UNIVERSITY · 2024 · $1,114,452

## Abstract

Project Summary
ICCRN is building the infrastructure (personnel, equipment, and systems [policies and procedures]) for clinical
research within a Federally Qualified Health Center – Innercare - that serves a rural, border community in
Southern California, specifically Imperial and South Riverside Counties. The ICCRN research infrastructure is
intended to support both observational (e.g., cohort studies; secondary analyses using electronic health record
[EHR] data) and intervention research (from efficacy to pragmatic trials). In this administrative supplement
application, we propose to augment research activities already approved under the prime contract, including
primary data collection of various social determinants of health (SDOH) using PhenX measures among
patients with uncontrolled diabetes and women receiving prenatal and postpartum care through Innercare.
These data will form the basis of our Common Data Elements (CDEs), data that will be harmonized with other
clinical network sites. Identifying CDEs, as well as protocols and processes for data sharing and harmonization
with other clinical network sites, has the potential to increase data interoperability and contribute generalizable
knowledge relevant to address health disparities. The Specific Aims of this Administrative Supplement include:
AIM 1 – Promote MHHD research by augmenting research staff support, including within the clinical partner
organization. AIM 2 – a. PP1: Identify SDOH relevant to diabetes management and control, and treatment
adherence. PP1 sample size is increased from N=126 to N=198 to support additional moderation and
mediation analyses. In addition, PP1 T2 (3 months post-baseline) data collection is expanded to include the
collection of additional PhenX measures from cohort participants; b. Identify SDOH relevant to adverse
pregnancy outcomes (APOs). PP2 is augmented to include primary data collection of PhenX and other
measures from a systematic sample of postpartum patients (N=600). In addition, PP2 is expanded to include
qualitative data collection from patients (N=10). AIM 3 – Support data harmonization with other CRNHE clinical
sites for rapid identification of new project ideas and dissemination of local and network-harmonized data to
patient, organizational, and community stakeholders. Completion of Administrative Supplement AIMS 1-3 will
augment both local and national efforts to identify important modifiable determinants to inform future
interventions (as in the case of PP2), and determinants of treatment effectiveness (as in the case of PP1).
Harmonized data with other network sites will contribute significant evidence for SDOH relevant across diverse
populations who share some characteristics (e.g., patients of a Federally Qualified Health Center, education
level) but not others (e.g., race/ethnicity, immigration status).

## Key facts

- **NIH application ID:** 11191312
- **Project number:** 3UH3MD018353-03S1
- **Recipient organization:** SAN DIEGO STATE UNIVERSITY
- **Principal Investigator:** GUADALUPE X AYALA
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,114,452
- **Award type:** 3
- **Project period:** 2022-09-24 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11191312

## Citation

> US National Institutes of Health, RePORTER application 11191312, Imperial County Clinical Research Network for Health Equity (Administrative Supplement) (3UH3MD018353-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11191312. Licensed CC0.

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