# Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY)

> **NIH NIH P20** · LOUISIANA STATE UNIV HSC SHREVEPORT · 2024 · $219,000

## Abstract

This study aims to investigate the association between plasma volatile organic compounds (VOCs) and 
oxidative balance scores (OBS) as potential biomarkers for cardiovascular disease (CVD) risk in patients 
with substance use disorder (SUD). Using data from the National Center for Health Statistics (2000-2024) 
involving 101,316 participants, we will calculate OBS and examine the correlations between OBS and 
plasma VOC levels in individuals with and without SUD, as well as in patients with and without CVD. Our 
hypothesis is that substance use increases VOC exposure, disrupts oxidative balance, and elevates CVD 
risk. Additionally, we will explore the clinical significance of VOCs in relation to oxidative damage 
biomarkers and their impact on CVD risk in SUD patients. Utilizing plasma samples from 800 patients at 
our Center for Cardiovascular Diseases and Sciences, we will identify SUD cases and controls, measure 
oxidative damage biomarkers (8-hydroxy-2'-deoxyguanosine (8-OHdG) and protein carbonyls), and 
quantify VOC levels and oxidative stress biomarkers in plasma. We hypothesize that SUD increases VOC 
levels, induces oxidative stress, and contributes to CVD risk. This research will create a comprehensive 
data repository and generate preliminary data to support an R01 grant proposal. By leveraging 
epidemiological data and clinical data, we aim to establish a centralized database for managing 
information on plasma VOC levels, oxidative balance scores, oxidative stress biomarkers, and CVD risk in 
SUD patients. The preliminary data will highlight a novel approach linking VOC exposure, oxidative stress, 
and CVD risk, emphasizing the public health implications and potential for identifying new biomarkers and 
therapeutic targets. This work aims to enhance our understanding of the interplay between environmental 
exposures, substance use, and cardiovascular health, ultimately guiding future research and intervention 
strategies.

## Key facts

- **NIH application ID:** 11194080
- **Project number:** 5P20GM121307-07
- **Recipient organization:** LOUISIANA STATE UNIV HSC SHREVEPORT
- **Principal Investigator:** Mohammad Alfrad Nobel Bhuiyan
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $219,000
- **Award type:** 5
- **Project period:** 2024-09-17 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11194080

## Citation

> US National Institutes of Health, RePORTER application 11194080, Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY) (5P20GM121307-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11194080. Licensed CC0.

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