Abstract This application describes the approaches to establish the coordinating center (CC) for NHLBI’s artificial intelligence initiative (NHLBI-AI). Goals of the NHLBI-AI initiative is to enable precision medicine for heart, lung, blood, and sleep Health by 1) developing a suite of Artificial Intelligence (AI) models, 2) supporting the HLBS and AI research communities, 3) developing and providing access to an appropriate array of vetted AI tools, and 4) supporting modular research programs focused on specific disease areas. Background Goals of the NHLBI-AI initiative is to enable precision medicine for heart, lung, blood, and sleep Health, specifically, it will 1) develop a suite of Artificial Intelligence (AI) models that have a transformative impact on discovery research involving heart, lung, blood, and sleep (HLBS) health and disease, 2) Support the HLBS and AI research communities by providing unique, high-value, machine-readable biomedical datasets in a secure computing environment, 3) develop and provide access to an appropriate array of vetted AI tools that can be used within a secure computing environment with minimal risk of data leakage, and 4) support modular research programs focused on deep phenotyping and systems biology approaches to understanding HLBS health, deconstructing HLBS conditions, and identifying potential treatment targets. The NHLBI is establishing the Artificial Intelligence – Coordinating Center (AI-CC) to serve as a central administrative hub for building other components of NHLBI-AI and administratively supporting those components to accomplish the goal of this initiative. The initial components will include AI data science center (DSC), precision medicine coordinating center (PMCC), individual AI projects (IAPs), and disease modules, such as pulmonary fibrosis and women’s health. In this application, women’s health will be used as an example to describe the Westat’s approaches to establish the AI-CC.