The current influenza H5N1 outbreak is an ongoing public health situation that has been observed in various regions throughout the US. H5N1 is a highly pathogenic avian influenza virus that primarily affects birds but can also infect other animals, including cattle (bovine H5N1). The objective of this Task Order supports NIAID’s goal to conduct phase 1 and phase 2 trials on H5N1 influenza vaccines to generate data to inform decisions on which candidates to support for advanced development.