MANUFACTURE AND PRECLINICAL TESTING OF SITE BLOCKING OLIGONUCLEOTIDES (SBO)

NIH RePORTER · NIH · N01 · $1,899,037 · view on reporter.nih.gov ↗

Abstract

This document outlines the scope of work and details necessary to provide a proposal for transfer of the current procedures for producing and testing research supplies, manufacture, and qualification of master cell banks (MCB) and viral stocks (MVSS), analytical methods development and qualification, production of reference standard, process development and scale-up, cGMP manufacturing of vHCA8*, and drug substance and drug product stability testing. It is important to note that, due to the nature of the vector, sterile filtration of the drug product is not possible and all manufacturing steps – upstream, downstream, and formulation/fill of drug product – must be performed under aseptic processing conditions.

Key facts

NIH application ID
11211981
Project number
75N95022D00023-0-759502400001-1
Recipient
ADVANCED BIOSCIENCE LABORATORIES, INC.
Principal Investigator
CARY RETTERER
Activity code
N01
Funding institute
NIH
Fiscal year
2024
Award amount
$1,899,037
Award type
Project period
2024-02-09 → 2027-02-08