# Innovations in Functional B Cell Epitope Discovery for Lyme Disease

> **NIH NIH N01** · NYSDOH/HEALTH RESEARCH, INC. · 2024 · $1,809,220

## Abstract

The goal of the proposal is to generate comprehensive human B cell epitope maps of major immunodominant surface lipoproteins of Borrelia burgdorferi, the causative agent of Lyme disease. Lyme disease is the most common vector-borne infection in the United States, with an estimated 450,000 cases per year. Epitope mapping lipoproteins on the surface of B. burgdorferi will advance the development of Lyme disease vaccines, therapeutics, and diagnostics in the United States and abroad.

## Key facts

- **NIH application ID:** 11215874
- **Project number:** 75N93024C00069-0-9999-1
- **Recipient organization:** NYSDOH/HEALTH RESEARCH, INC.
- **Principal Investigator:** NICHOLAS MANTIS
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,809,220
- **Award type:** —
- **Project period:** 2024-09-16 → 2025-09-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11215874

## Citation

> US National Institutes of Health, RePORTER application 11215874, Innovations in Functional B Cell Epitope Discovery for Lyme Disease (75N93024C00069-0-9999-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11215874. Licensed CC0.

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