# Evaluation of Physiological Monitoring in Toxicology using 2-Ethyltoluene as a case study

> **NIH NIH N01** · BATTELLE CENTERS/PUB HLTH RES & EVALUATN · 2024 · $2,523,707

## Abstract

This project conducted for the Division of Translational Toxicology (DTT) is designed to evaluate the use of physiological monitoring parameters (blood pressure, heart rate, heart rate variability, ecg etc.) in routine toxicology assessments. These parameters are easy translatable to humans, as passive metrics collected and use for human health on a routine basis. These parameters may also offer early indicators of an animal developing a toxic outcome from exposure to a chemical that could be detected before the animal is euthanized, and could allow early intervention for laboratory animal medicine. Telemetry-implanted animals were exposed to a test article in whole-body inhalation chambers for 4 weeks to determine if physiological monitoring parameters would be more sensitive or would be earlier indicators of toxicity when compared to apical outcomes (e.g. histopathology) for known toxic effects of the test article.

## Key facts

- **NIH application ID:** 11216082
- **Project number:** 75N96024C00005-0-9999-8
- **Recipient organization:** BATTELLE CENTERS/PUB HLTH RES & EVALUATN
- **Principal Investigator:** DAWN FALLACARA
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,523,707
- **Award type:** —
- **Project period:** 2024-09-16 → 2025-09-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11216082

## Citation

> US National Institutes of Health, RePORTER application 11216082, Evaluation of Physiological Monitoring in Toxicology using 2-Ethyltoluene as a case study (75N96024C00005-0-9999-8). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11216082. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*