# SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH)TRITON SYSTEMS INC:1185597 [24-001257]

> **NIH NIH N43** · TRITON SYSTEMS, INC. · 2024 · $299,976

## Abstract

This Phase I SBIR contract is in support of Development of novel In-vitro and In-vivo Models to support NeuroHIV Research. Upon the completion of Phase I, This contract aims to 1) Develop and create an integrated BBB tissue analog and incorporate a 3D micro-TEER system to assess the baseline of barrier integrity 2) Establish the co-culture of 3D BBB with organoidal-neurosphere, and validate the key gene expressions, BBB permeability, and neuron functions in our MPS platform 3) Validate the MPS platform can be used to study neuroinflammation and neuroimmune communication

## Key facts

- **NIH application ID:** 11222473
- **Project number:** 75N95024C00036-0-9999-1
- **Recipient organization:** TRITON SYSTEMS, INC.
- **Principal Investigator:** Jing Bai
- **Activity code:** N43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $299,976
- **Award type:** —
- **Project period:** 2024-09-23 → 2025-09-22

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11222473

## Citation

> US National Institutes of Health, RePORTER application 11222473, SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH)TRITON SYSTEMS INC:1185597 [24-001257] (75N95024C00036-0-9999-1). Retrieved via AI Analytics 2026-06-07 from https://api.ai-analytics.org/grant/nih/11222473. Licensed CC0.

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