# SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH) VALA SCIENCES INC.:1165050 [24-004928]

> **NIH NIH N43** · VALA SCIENCES, INC. · 2024 · $50,000

## Abstract

This Phase I SBIR contract is in support of Development of novel In-vitro and In-vivo Models to support NeuroHIV
Research. hiPSC-NeuroHIV assay, an in vitro model system that mimics certain cellular components of the human
brain using cells derived from human induced pluripotent stem cells (hiPSCneurons/ microglia/astrocytes).
The hiPSC-NeuroHIV assay system will enable HIV-therapeutics and cART mixtures to be tested for both NeuroHIV
effects (neurotoxicity), and for efficacy at blocking HIV replication.
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## Key facts

- **NIH application ID:** 11222476
- **Project number:** 75N95024C00035-0-9999-1
- **Recipient organization:** VALA SCIENCES, INC.
- **Principal Investigator:** PATRICK M MCDONOUGH
- **Activity code:** N43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $50,000
- **Award type:** —
- **Project period:** 2024-09-27 → 2025-09-26

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11222476

## Citation

> US National Institutes of Health, RePORTER application 11222476, SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH) VALA SCIENCES INC.:1165050 [24-004928] (75N95024C00035-0-9999-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11222476. Licensed CC0.

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