# Genetic and developmental mechanisms that underlie craniofacial (co)variation

> **NIH DE R01** · UNIVERSITY OF MASSACHUSETTS AMHERST · 2026 · $357,611

## Abstract

Abstract/Summary:
The vertebrate craniofacial skeleton is a dynamic organ that arises and is maintained through an
intricate balance of genetic and environmental inputs. Disruptions to either can lead to deleterious
health outcomes. While significant progress has been made toward understanding the genetic and
cellular mechanisms that underlie early craniofacial patterning, much less is known about the basis for
craniofacial variation that manifests over extended periods of development, and depends upon the
environmental context in which it occurs. Whether it's the physical interactions between cells and
tissues within the developing embryo, or the mechanic forces imposed on the system, these contexts
will determine how genetically-encoded systems unfold over time to determine craniofacial geometry.
 Implicit to these ideas is feedback in the system. Feedback is how disparate developmental units
come together to form integrated functional systems - e.g., reciprocal signaling between adjacent but
developmentally distinct tissues. It is also necessary for normal growth and homeostasis in kinetic
systems - e.g., progenitor cells must sense environmental inputs, including mechanical load, and adjust
developmental processes accordingly. Broadly speaking this proposal seeks to understand how both
types of feedback are regulated at the genetic level. In doing so, three specific questions will be
addressed: (1) What are the genes that contribute to craniofacial shape? (2) Do they exert their effects
on more than one tissue, either via pleiotropy or as part of the same signaling pathway? (3) How do
these loci interact with the environment, via mechanosensing, to affect variation in facial form?
 Cichlid fishes will be used as the experimental model, as they have undergone extensive
evolutionary modifications of their skulls and jaws in a very brief period of time, making them ideal for
genetic/genomic mapping. Cichlids are also well known for their capacity to remodel their j

## Key facts

- **NIH application ID:** 11231251
- **Project number:** 5R01DE026446-09
- **Recipient organization:** UNIVERSITY OF MASSACHUSETTS AMHERST
- **Principal Investigator:** Craig  Albertson
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** DE
- **Fiscal year:** 2026
- **Award amount:** $357,611
- **Award type:** 5
- **Project period:** 2017-01-01T00:00:00 → 2027-11-30T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11231251

## Citation

> US National Institutes of Health, RePORTER application 11231251, Genetic and developmental mechanisms that underlie craniofacial (co)variation (5R01DE026446-09). Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/grant/nih/11231251. Licensed CC0.

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