# California Partnership for Personalized Nutrition

> **NIH HD UG1** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2026 · $2,844,024

## Abstract

Project Summary: Poor diet and sedentary behaviors are associated with some of the leading causes of
premature death in the U.S. While nutritionists understand that there are a variety of eating behaviors that have
positive benefits to health and function in general terms, it has been difficult to tailor dietary recommendations to
the individual. Public health recommendations and marketing that aim to improve ‘diet quality’ (or complementary
outcomes, such as physical activity) have been hampered by a broad brush ‘one-size fits all’ approach without
distinguishing individualized needs. A big challenge to design of strategies for more personalized public health
is the paucity of large-scale interventions that have tested person-to-person differences in physiological
responses to standardized foods or diet patterns. The premise of the NIH Nutrition for Precision Health program
and this application to establish the California Partnership for Personalized Nutrition Clinical Center is that
variance in dietary patterns and physiological responses to patterns and specific foods are shaped by disparate
factors including complex genetic, microbiome, psychosocial, human ecology, and metabolic variables. We aim
to examine which factor or combination of factors influence responses to a test meal composed of strategic
ingredients that interrogate multiple biological systems in parallel, population-wide but with a consideration of
sub-groups that differ with respect to glucose control and microbiome (type 2 diabetic, pre-diabetic, and non-
diabetic persons). In addition, the differential (intra- and interindividual) responses to three disparate diets
(Mediterranean, low-carbohydrate, and high-carbohydrate) will be tested in free-living and domiciled conditions,
to characterize microbiota shifts and to associate diet with changes in multi-system physiology and
chronobiology. Finally, the study design also provides biospecimens for metabolomics, chemistry, and
microbiome; advanced 

## Key facts

- **NIH application ID:** 11233153
- **Project number:** 5UG1HD107711-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Sean Harrison Adams; ALEXANDER D BOROWSKY; Brian Joseph Bennett; Marc T Goodman; Zhaoping  Li; FRANCENE M STEINBERG
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** HD
- **Fiscal year:** 2026
- **Award amount:** $2,844,024
- **Award type:** 5
- **Project period:** 2021-12-10T00:00:00 → 2026-11-30T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11233153

## Citation

> US National Institutes of Health, RePORTER application 11233153, California Partnership for Personalized Nutrition (5UG1HD107711-05). Retrieved via AI Analytics 2026-05-17 from https://api.ai-analytics.org/grant/nih/11233153. Licensed CC0.

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