# Investigating the effect of mechanical compliance of metamaterial interbody cages on spinal fusion progress in vivo

> **NIH EB R21** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2026 · $162,245

## Abstract

PROJECT SUMMARY
There is an unmet need for understanding the complex relationships between the compliance of
interbody fusion cages, interbody loading, load-sharing, and the progression of spinal fusion in vivo.
Interbody fusion cages are spinal implants that have become highly popular over the last decade. An ideal
interbody fusion cage should be sufficiently stiff and strong to limit interbody motion and relieve the pressure that
may be causing pain, while “compliant” enough to allow sufficient load to be transferred through the spine to
maintain bone. We propose to investigate the effect of the mechanical compliance of interbody cages on
the spinal fusion rate and the subsidence of spinal segments in ovine models. To this aim, we will create
the first-of-their-kind compliant metamaterial fusion cages with tunable stiffness, porosity and energy
absorption, and will implant them in ambulatory vertebrate animals. We hypothesize that the proposed
metamaterial interbody cages with local compliance and reduced stiffness foster more consistent load-sharing
during the full range of motion from flexion to extension. This is clinically significant because load-sharing through
the interbody space stimulates bone formation and maturation and may ultimately lead to better outcomes.
Therefore, we hypothesize that the compliant metamaterial cages introduce a softer stabilization approach
leading to a faster bone formation and better fusion. Our first objective will be to perform topology optimization
to develop a series of “mechanically-optimized” metamaterial cages, which can be adapted to function in animal
models. We will create a computational framework that can serve as a universal method for the accelerated
design of the compliant fusion cages across a full relative density range with various biocompatible material
options. The fabricated cages will be mechanically tested following the protocols described by the ASTM
standards F2077 and F2267 to establish their static/dyn

## Key facts

- **NIH application ID:** 11259437
- **Project number:** 5R21EB034457-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Amir  Alavi
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** EB
- **Fiscal year:** 2026
- **Award amount:** $162,245
- **Award type:** 5
- **Project period:** 2024-01-02T00:00:00 → 2026-12-31T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11259437

## Citation

> US National Institutes of Health, RePORTER application 11259437, Investigating the effect of mechanical compliance of metamaterial interbody cages on spinal fusion progress in vivo (5R21EB034457-03). Retrieved via AI Analytics 2026-05-19 from https://api.ai-analytics.org/grant/nih/11259437. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*