# Shared Resources 06: Drug Discovery Shared Resource (DDSR)

> **NIH CA P30** · OHIO STATE UNIVERSITY · 2026 · $327,715

## Abstract

PROJECT SUMMARY – DRUG DISCOVERY SHARED RESOURCE (DDSR)
The Ohio State University Comprehensive Cancer Center (OSUCCC) Drug Discover Shared Resource
(DDSR) supports OSUCCC members to discover and develop small molecules as probes of molecular pathways
implicated in tumor growth. We work with investigators to optimize the properties of chemical agents against
diverse therapeutic targets to advance preclinical and clinical development. This facility was initially established
in 2011 as the developing Medicinal Chemistry Shared Resource (MCSR). The MCSR became a full CCSG
shared resource in 2015. In 2022, we added high throughput screening (HTS) capabilities and renamed this
facility the Drug Discovery Shared Resource. The DDSR comprises two integrated cores: Medicinal Chemistry
(DDSR-MC) and High-Throughput / High-Content Screening (DDSR-HTS). These cores provide crucial services
for investigators seeking to identify new therapeutic candidates and tool compounds. The DDSR supports
investigators conducting preclinical in vitro and in vivo studies by offering multidisciplinary expertise in medicinal
chemistry, process chemistry, rational structure-based design, molecular pharmacology, and modern plate-
based screening technologies. Key services provided by DDSR-MC include custom synthesis and lead
optimization, including structure activity relationship analysis and structure-based optimization. Key services
provided by the DDSR-HTS include access to plated libraries of over 150,000 drugs and diversity compounds
that can be manipulated with automated liquid handlers. These can be analyzed for biological activity using
multiple detection systems including modern high content confocal microscopy and high throughput flow
cytometry. The Specific Aims of the DDSR are: 1) enable researchers to develop chemical probes of cancer
biology; 2) optimize hit and lead molecules through the design and synthesis of analogs with improved drug-like
properties for translational development

## Key facts

- **NIH application ID:** 11263198
- **Project number:** 2P30CA016058-50
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Chad E. Bennett
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** CA
- **Fiscal year:** 2026
- **Award amount:** $327,715
- **Award type:** 2
- **Project period:** 1997-09-12T00:00:00 → 2031-03-31T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11263198

## Citation

> US National Institutes of Health, RePORTER application 11263198, Shared Resources 06: Drug Discovery Shared Resource (DDSR) (2P30CA016058-50). Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/grant/nih/11263198. Licensed CC0.

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