PROJECT SUMMARY – HEMATOLOGY TISSUE BANK SHARED RESOURCE (HTBSR) The Ohio State University Comprehensive Cancer Center (OSUCCC) Hematology Tissue Bank Shared Resource (HTBSR) is a longstanding biobank, established in 1997, that procures, processes, and stores biologic material from consenting patients with hematologic diseases. The HTBSR procures samples in two ways: 1) via a general biobanking protocol for future research; and 2) via specific clinical research protocols with special collection needs. The major services of the HTBSR are consenting patients, procuring samples (e.g., blood, bone marrow, and leukapheresis products) as directed by the general or a specific IRB protocol, assessing sample quality, providing fresh samples to investigators or processing them for storage, providing an oversight process for use of samples and data, and delivering de-identified samples and data to approved recipients. Investigators receive samples identified phenotypically or genetically, along with clinical data and available pathology data (including standard of care immunophenotyping and genetic sequencing panels). During the current cycle, Dr. Lapo AlinariLHM served as the HTBSR Director. The Specific Aims of the HTBSR are to: 1) consent subjects and procure samples from patients with hematologic diseases; 2) uniformly process, characterize and store biospecimens using state-of-the art procedures; and 3) provide de-identified biospecimens with associated clinical, pathological and genomic data to OSUCCC researchers and to outside institutions so that they can correlate findings from patient samples with clinical or population-based outcomes. In addition to biospecimens procured from consented patients with hematologic diseases, the HTBSR procures, processes, and distributes fresh or cryopreserved peripheral blood samples from healthy donors, peripheral blood and bone marrow samples from allogeneic stem cell transplant recipients, and cell-therapy patients (Cell Therapy Ban